Biotransformation of three pharmaceutical active compounds by the fungus Phanerochaete chrysosporium in a fed batch stirred reactor under air and oxygen supply.
Identifieur interne : 000464 ( Main/Exploration ); précédent : 000463; suivant : 000465Biotransformation of three pharmaceutical active compounds by the fungus Phanerochaete chrysosporium in a fed batch stirred reactor under air and oxygen supply.
Auteurs : A I Rodarte-Morales [Espagne] ; G. Feijoo ; M T Moreira ; J M LemaSource :
- Biodegradation [ 1572-9729 ] ; 2012.
Descripteurs français
- KwdFr :
- Air (MeSH), Anti-inflammatoires (métabolisme), Bioréacteurs (MeSH), Biotransformation (MeSH), Cinétique (MeSH), Diclofenac (métabolisme), Dépollution biologique de l'environnement (MeSH), Ibuprofène (métabolisme), Naproxène (métabolisme), Oxydoréduction (MeSH), Oxygène (MeSH), Phanerochaete (métabolisme), Polluants chimiques de l'eau (métabolisme), Techniques de culture cellulaire en batch (MeSH).
- MESH :
English descriptors
- KwdEn :
- Air (MeSH), Anti-Inflammatory Agents (metabolism), Batch Cell Culture Techniques (MeSH), Biodegradation, Environmental (MeSH), Bioreactors (MeSH), Biotransformation (MeSH), Diclofenac (metabolism), Ibuprofen (metabolism), Kinetics (MeSH), Naproxen (metabolism), Oxidation-Reduction (MeSH), Oxygen (MeSH), Phanerochaete (metabolism), Water Pollutants, Chemical (metabolism).
- MESH :
- chemical , metabolism : Anti-Inflammatory Agents, Diclofenac, Ibuprofen, Naproxen, Water Pollutants, Chemical.
- metabolism : Phanerochaete.
- Air, Batch Cell Culture Techniques, Biodegradation, Environmental, Bioreactors, Biotransformation, Kinetics, Oxidation-Reduction, Oxygen.
Abstract
White-rot fungi are a group of microorganisms capable of degrading xenobiotic compounds, such as polycyclic aromatic hydrocarbons or synthetic dyes, by means of the action of extracellular oxidative enzymes secreted during secondary metabolism. In this study, the transformation of three anti-inflammatory drugs: diclofenac, ibuprofen and naproxen were carried out by pellets of Phanerochaete chrysosporium in fed-batch bioreactors operating under continuous air supply or periodic pulsation of oxygen. The performance of the fungal reactors was steady over a 30-day treatment and the effect of oxygen pulses on the pellet morphology was evidenced. Complete elimination of diclofenac was achieved in the aerated and the oxygenated reactors, even with a fast oxidation rate in the presence of oxygen (77% after 2 h), reaching a total removal after 23 h. In the case of ibuprofen, this compound was completely oxidized under air and oxygen supply. Finally, naproxen was oxidized in the range of 77 up to 99% under both aeration conditions. These findings demonstrate that the oxidative capability of this microorganism for the anti-inflammatory drugs is not restricted to an oxygen environment, as generally accepted, since the fungal reactor was able to remove these compounds under aerated and oxygenated conditions. This result is very interesting in terms of developing viable reactors for the oxidation of target compounds as the cost of aeration can be significantly reduced.
DOI: 10.1007/s10532-011-9494-9
PubMed: 21695453
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Feijoo</name></author><author><name sortKey="Moreira, M T" sort="Moreira, M T" uniqKey="Moreira M" first="M T" last="Moreira">M T Moreira</name></author><author><name sortKey="Lema, J M" sort="Lema, J M" uniqKey="Lema J" first="J M" last="Lema">J M Lema</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:21695453</idno><idno type="pmid">21695453</idno><idno type="doi">10.1007/s10532-011-9494-9</idno><idno type="wicri:Area/Main/Corpus">000491</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000491</idno><idno type="wicri:Area/Main/Curation">000491</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000491</idno><idno type="wicri:Area/Main/Exploration">000491</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Biotransformation of three pharmaceutical active compounds by the fungus Phanerochaete chrysosporium in a fed batch stirred reactor under air and oxygen supply.</title><author><name sortKey="Rodarte Morales, A I" sort="Rodarte Morales, A I" uniqKey="Rodarte Morales A" first="A I" last="Rodarte-Morales">A I Rodarte-Morales</name><affiliation wicri:level="4"><nlm:affiliation>Department of Chemical Engineering, School of Engineering, University of Santiago de Compostela, Santiago de Compostela, Spain. angelica.rodarte@usc.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Chemical Engineering, School of Engineering, University of Santiago de Compostela, Santiago de Compostela</wicri:regionArea><orgName type="university">Université de Saint-Jacques-de-Compostelle</orgName><placeName><settlement type="city">Santiago de Compostela</settlement><region nuts="2" type="region">Galice</region></placeName></affiliation></author><author><name sortKey="Feijoo, G" sort="Feijoo, G" uniqKey="Feijoo G" first="G" last="Feijoo">G. Feijoo</name></author><author><name sortKey="Moreira, M T" sort="Moreira, M T" uniqKey="Moreira M" first="M T" last="Moreira">M T Moreira</name></author><author><name sortKey="Lema, J M" sort="Lema, J M" uniqKey="Lema J" first="J M" last="Lema">J M Lema</name></author></analytic><series><title level="j">Biodegradation</title><idno type="eISSN">1572-9729</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Air (MeSH)</term><term>Anti-Inflammatory Agents (metabolism)</term><term>Batch Cell Culture Techniques (MeSH)</term><term>Biodegradation, Environmental (MeSH)</term><term>Bioreactors (MeSH)</term><term>Biotransformation (MeSH)</term><term>Diclofenac (metabolism)</term><term>Ibuprofen (metabolism)</term><term>Kinetics (MeSH)</term><term>Naproxen (metabolism)</term><term>Oxidation-Reduction (MeSH)</term><term>Oxygen (MeSH)</term><term>Phanerochaete (metabolism)</term><term>Water Pollutants, Chemical (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Air (MeSH)</term><term>Anti-inflammatoires (métabolisme)</term><term>Bioréacteurs (MeSH)</term><term>Biotransformation (MeSH)</term><term>Cinétique (MeSH)</term><term>Diclofenac (métabolisme)</term><term>Dépollution biologique de l'environnement (MeSH)</term><term>Ibuprofène (métabolisme)</term><term>Naproxène (métabolisme)</term><term>Oxydoréduction (MeSH)</term><term>Oxygène (MeSH)</term><term>Phanerochaete (métabolisme)</term><term>Polluants chimiques de l'eau (métabolisme)</term><term>Techniques de culture cellulaire en batch (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Diclofenac</term><term>Ibuprofen</term><term>Naproxen</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Phanerochaete</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anti-inflammatoires</term><term>Diclofenac</term><term>Ibuprofène</term><term>Naproxène</term><term>Phanerochaete</term><term>Polluants chimiques de l'eau</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Air</term><term>Batch Cell Culture Techniques</term><term>Biodegradation, Environmental</term><term>Bioreactors</term><term>Biotransformation</term><term>Kinetics</term><term>Oxidation-Reduction</term><term>Oxygen</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Air</term><term>Bioréacteurs</term><term>Biotransformation</term><term>Cinétique</term><term>Dépollution biologique de l'environnement</term><term>Oxydoréduction</term><term>Oxygène</term><term>Techniques de culture cellulaire en batch</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">White-rot fungi are a group of microorganisms capable of degrading xenobiotic compounds, such as polycyclic aromatic hydrocarbons or synthetic dyes, by means of the action of extracellular oxidative enzymes secreted during secondary metabolism. In this study, the transformation of three anti-inflammatory drugs: diclofenac, ibuprofen and naproxen were carried out by pellets of Phanerochaete chrysosporium in fed-batch bioreactors operating under continuous air supply or periodic pulsation of oxygen. The performance of the fungal reactors was steady over a 30-day treatment and the effect of oxygen pulses on the pellet morphology was evidenced. Complete elimination of diclofenac was achieved in the aerated and the oxygenated reactors, even with a fast oxidation rate in the presence of oxygen (77% after 2 h), reaching a total removal after 23 h. In the case of ibuprofen, this compound was completely oxidized under air and oxygen supply. Finally, naproxen was oxidized in the range of 77 up to 99% under both aeration conditions. These findings demonstrate that the oxidative capability of this microorganism for the anti-inflammatory drugs is not restricted to an oxygen environment, as generally accepted, since the fungal reactor was able to remove these compounds under aerated and oxygenated conditions. This result is very interesting in terms of developing viable reactors for the oxidation of target compounds as the cost of aeration can be significantly reduced.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21695453</PMID><DateCompleted><Year>2012</Year><Month>06</Month><Day>20</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1572-9729</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>1</Issue><PubDate><Year>2012</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Biodegradation</Title><ISOAbbreviation>Biodegradation</ISOAbbreviation></Journal><ArticleTitle>Biotransformation of three pharmaceutical active compounds by the fungus Phanerochaete chrysosporium in a fed batch stirred reactor under air and oxygen supply.</ArticleTitle><Pagination><MedlinePgn>145-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10532-011-9494-9</ELocationID><Abstract><AbstractText>White-rot fungi are a group of microorganisms capable of degrading xenobiotic compounds, such as polycyclic aromatic hydrocarbons or synthetic dyes, by means of the action of extracellular oxidative enzymes secreted during secondary metabolism. In this study, the transformation of three anti-inflammatory drugs: diclofenac, ibuprofen and naproxen were carried out by pellets of Phanerochaete chrysosporium in fed-batch bioreactors operating under continuous air supply or periodic pulsation of oxygen. The performance of the fungal reactors was steady over a 30-day treatment and the effect of oxygen pulses on the pellet morphology was evidenced. Complete elimination of diclofenac was achieved in the aerated and the oxygenated reactors, even with a fast oxidation rate in the presence of oxygen (77% after 2 h), reaching a total removal after 23 h. In the case of ibuprofen, this compound was completely oxidized under air and oxygen supply. Finally, naproxen was oxidized in the range of 77 up to 99% under both aeration conditions. These findings demonstrate that the oxidative capability of this microorganism for the anti-inflammatory drugs is not restricted to an oxygen environment, as generally accepted, since the fungal reactor was able to remove these compounds under aerated and oxygenated conditions. This result is very interesting in terms of developing viable reactors for the oxidation of target compounds as the cost of aeration can be significantly reduced.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rodarte-Morales</LastName><ForeName>A I</ForeName><Initials>AI</Initials><AffiliationInfo><Affiliation>Department of Chemical Engineering, School of Engineering, University of Santiago de Compostela, Santiago de Compostela, Spain. angelica.rodarte@usc.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feijoo</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Moreira</LastName><ForeName>M T</ForeName><Initials>MT</Initials></Author><Author ValidYN="Y"><LastName>Lema</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>06</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biodegradation</MedlineTA><NlmUniqueID>9100834</NlmUniqueID><ISSNLinking>0923-9820</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical><Chemical><RegistryNumber>144O8QL0L1</RegistryNumber><NameOfSubstance UI="D004008">Diclofenac</NameOfSubstance></Chemical><Chemical><RegistryNumber>57Y76R9ATQ</RegistryNumber><NameOfSubstance UI="D009288">Naproxen</NameOfSubstance></Chemical><Chemical><RegistryNumber>S88TT14065</RegistryNumber><NameOfSubstance UI="D010100">Oxygen</NameOfSubstance></Chemical><Chemical><RegistryNumber>WK2XYI10QM</RegistryNumber><NameOfSubstance UI="D007052">Ibuprofen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000388" MajorTopicYN="N">Air</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061249" MajorTopicYN="N">Batch Cell Culture Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001673" MajorTopicYN="N">Biodegradation, Environmental</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019149" MajorTopicYN="N">Bioreactors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001711" MajorTopicYN="N">Biotransformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>02</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>06</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21695453</ArticleId><ArticleId 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Feijoo</name><name sortKey="Lema, J M" sort="Lema, J M" uniqKey="Lema J" first="J M" last="Lema">J M Lema</name><name sortKey="Moreira, M T" sort="Moreira, M T" uniqKey="Moreira M" first="M T" last="Moreira">M T Moreira</name></noCountry><country name="Espagne"><region name="Galice"><name sortKey="Rodarte Morales, A I" sort="Rodarte Morales, A I" uniqKey="Rodarte Morales A" first="A I" last="Rodarte-Morales">A I Rodarte-Morales</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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